Low-dose aspirin linked to 70% lower dementia risk, but there's a catch
Researchers from Monash University found that low-dose aspirin may reduce dementia risk by 70% in individuals with specific genetic profiles related to platelet counts. However, the study also noted a significant increase in the risk of major bleeding for these same individuals.
Why it matters
This highlights the potential for precision medicine in dementia prevention while underscoring the trade-offs between therapeutic benefits and safety risks.
A new analysis from Monash University suggests that low-dose aspirin may be linked to a dramatically lower risk of dementia in older adults with certain genetic characteristics. Researchers found that people with a specific genetic profile who took aspirin had a 70 percent lower relative risk of developing dementia, raising the possibility that genetic testing could eventually help identify people who might benefit from preventive treatments.
The findings, published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association , were based on genetic data from more than 13,500 participants in the landmark ASPREE Trial (Aspirin in Reducing Events in the Elderly). Scientists examined whether differences in participants' genes could help explain why aspirin might affect dementia risk differently from one person to another.
Aspirin Linked to 70% Lower Dementia Risk in Certain People
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