Loss of Y Chromosome in Men Might Be an Early Indication of Cancer, Finds Study

A genetic change that becomes more common in men with age could help scientists identify some cancers at an earlier stage, according to new research. The study found that loss of the Y chromosome in cells may occur not only inside tumours but also in normal-looking tissue surrounding a tumour.

The findings published in the journal ‘JCI Insight’ suggest that loss of the Y chromosome could potentially act as an early warning sign of cancer development in men. However, more research is needed before it can be used as a routine cancer screening tool.

Men usually have one X and one Y chromosome in each cell. The Y chromosome carries genes involved in male biological development and other cellular functions.