Loss of LATS1 promotes immune evasion in colon cancer via YAP/TEAD-driven lactate metabolism reprogramming
A study reveals that the loss of the LATS1 protein in colon cancer cells promotes immune evasion by reprogramming lactate metabolism via the YAP/TEAD pathway. Inhibiting the LDHA enzyme was found to reverse these immunosuppressive effects, suggesting a potential therapeutic target.
Why it matters
Understanding the metabolic mechanisms of tumor immune evasion provides new pathways for developing more effective cancer immunotherapies.
Scientific Reports ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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