Lipopolysaccharide priming confers trained immunity and enhances antiviral defense against Sendai virus via STAT1/2 signaling
Researchers have discovered that priming the immune system with lipopolysaccharide (LPS) can induce 'trained immunity' in mice, providing enhanced protection against respiratory viruses like Sendai virus. This process involves the functional reprogramming of innate immune cells, which leads to a more efficient antiviral response through STAT1/2 signaling.
Why it matters
This finding suggests a potential new strategy for developing broad-spectrum antiviral therapies by leveraging the innate immune system's memory capabilities.
Scientific Reports ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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