Like a molecular shrink ray, AI tool redesigns proteins without sacrificing function
Duke University researchers have developed an AI tool called 'Raygun' that redesigns proteins by leveraging protein language models. The tool allows for extensive modifications to protein size and structure while maintaining biological function.
Why it matters
This technology could significantly accelerate the development of targeted medicines and advance biological research by enabling precise protein engineering.
edited by Swati Mestri , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add as preferred source Rohit Singh, Ph.D.; Kapil Devkota, Ph.D.; Joey Mao; Scott Soderling, Ph.D., and Daichi Shonai, in the lab at Duke University School of Medicine. Credit: Eamon Queeney / Duke University School of Medicine Researchers at Duke University School of Medicine have developed an artificial intelligence framework that can redesign proteins on a scale previously seen only in natural evolution. The tool can create shorter, longer and highly modified versions of proteins while preserving their structure and function.
Rather than designing new proteins from scratch, the method, called Raygun , builds on protein language models —AI systems trained on millions of natural protein sequences—to make extensive modifications to existing proteins.
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