Largest ever ‘map’ of autism may hold clues for new targeted therapies

Scientists have used artificial intelligence to create a comprehensive molecular map of how genetic mutations associated with autism rewire the brain. This breakthrough could allow researchers to develop targeted drug therapies by focusing on protein interactions rather than individual genes.
Why it matters
This research provides a potential roadmap for developing the first effective pharmacological treatments for autism spectrum disorder.
This new map shows the network of autism spectrum disorder-related protein-protein interactions. - The Quantitative Biosciences Institute at the University of California, San Francisco Scientists are getting a step closer to understanding exactly how autism develops in the brain – and what might work to treat it.
Using artificial intelligence and data on tiny brains grown in the lab, researchers have mapped out the ways in which certain genetic mutations that are associated with autism can rewire the brain and lead to the condition. The molecular map, published Thursday in the journal Science , could help inform more targeted therapies for autism.
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