Investigating the role of G-quadruplex-associated duplex stem loops in Trabectedin’s mechanism of action
This study investigates how the antitumor drug Trabectedin interacts with G-quadruplex (G4) DNA structures. Researchers found that while the drug can stabilize G4-duplex architectures, it maintains a stronger affinity for standard duplex DNA.
Why it matters
Refining the mechanism of action for chemotherapy drugs like Trabectedin can lead to more effective cancer treatments and better understanding of drug-DNA interactions.
Scientific Reports ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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