Inducing transcription in a gene desert is associated with locally increased replication activity
Researchers used a doxycycline-inducible system in mouse embryonic stem cells to study the relationship between gene transcription and DNA replication. They found that inducing transcription in a gene-poor region leads to a localized increase in replication activity, though it does not fully shift the region to an early-replicating state.
Why it matters
Understanding the interplay between transcription and replication is fundamental to understanding genome organization and how cells manage DNA stability.
Scientific Reports ( 2026 ) Cite this article
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