Inducing transcription in a gene desert is associated with locally increased replication activity
Researchers investigated the relationship between transcription and DNA replication by inserting a reporter cassette into a gene-poor region of mouse embryonic stem cells. The study found that inducing transcription in these 'gene deserts' leads to a localized increase in replication activity.
Why it matters
Understanding the interplay between transcription and genome replication provides fundamental insights into how cells maintain genomic stability and regulate gene expression.
Scientific Reports ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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