IgA Nephropathy Recurrence Risks After Transplant
A Danish study of 118 kidney transplant patients found that younger age at diagnosis and living donor transplants are linked to higher risks of IgA nephropathy recurrence. The research highlights that recurrence significantly increases the risk of graft failure, emphasizing the need for better risk identification.
Why it matters
Understanding recurrence factors is critical for improving long-term outcomes and survival rates for kidney transplant recipients.
RECURRENT immunoglobulin A ( IgA ) nephropathy after kidney transplantation was associated with younger age at diagnosis, faster progression to kidney failure, and receipt of kidneys from living or genetically related donors in a Danish multicentre cohort study. The research assessed the incidence of biopsy confirmed recurrent IgA nephropathy and identified clinical and donor related factors associated with recurrence risk. The study evaluated contemporary transplantation data from two Danish centres to further characterise recurrence patterns among patients with previous IgA nephropathy.
The study included 118 adults with biopsy proven IgA nephropathy who received a first kidney only transplantation between 1990 and 2020 across two Danish transplantation centres. Patients were followed for a median of 5.5 years to evaluate recurrence and outcomes after transplantation.
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