Human brain tissue grew to fill over 90% of missing cortex in mice

Stanford scientists have created a new model for studying human brain development by transplanting lab-grown human brain tissue into mice that were engineered to lack most of their cerebral cortex. Within months, the human tissue not only survived but expanded to occupy more than 90 percent of the cortical space, forming working connections with the mouse brain and spinal cord. The study titled 'Developmental xenocortication using human-derived organoids in mice' was published in Nature online on September 16.