HPV-HIV Coinfection May Accelerate Viral Persistence and Cancer Risk
A narrative review highlights that HIV-related immune dysfunction significantly increases the risk of persistent HPV infection and associated cancers. The study notes that individuals with HIV are up to six times more likely to experience HPV persistence compared to the general population.
Why it matters
Understanding the biological link between HIV and HPV is critical for developing targeted screening and prevention strategies for immunocompromised populations.
By LF Leslie Feldman A narrative review, published in HIV/AIDS , examined the complex relationship between human papillomavirus (HPV) and human immunodeficiency virus (HIV), focusing on how immune dysfunction associated with HIV may allow HPV infections to persist and increase the risk of HPV-related cancers. The review brings together evidence on the biological mechanisms, clinical consequences, and prevention strategies associated with HPV-HIV coinfection.
HPV is a common viral infection, and the immune system controls most infections. However, persistent infection with high-risk HPV types can lead to cellular changes and eventually contribute to cancers of the cervix, anus, genitals, mouth and throat. The review argues that HIV-related immune dysfunction can interfere with the body’s ability to clear HPV, creating conditions that favor persistent infection and cancer development.
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