How lung tumors hijack an ancient marine metabolic axis to promote malignant growth
Researchers at the Chinese Academy of Sciences have discovered a metabolic signaling axis in oysters that helps them survive thermal stress, which also appears to drive malignant growth in human lung cancer. The study reveals how this ancient mechanism stabilizes specific enzymes to maintain energy production in cancer cells.
Why it matters
Understanding this metabolic pathway could lead to new therapeutic strategies for treating lung adenocarcinoma by targeting the mechanisms that allow tumors to thrive under energy stress.
by Zhang Nannan, Chinese Academy of Sciences
edited by Sadie Harley , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add as preferred source The metazoan-conserved KAT2/HDACIIa–PGK–ALDO axis inhibits dual protein degradation systems to enhance glycolysis, linking oyster thermal tolerance to cancer progression. Credit: IOCAS Researchers at the Institute of Oceanology of the Chinese Academy of Sciences (IOCAS) have shown how a metabolic mechanism underlying thermal tolerance in intertidal oysters sheds light on malignant proliferation in human lung adenocarcinoma.
The research, published in PNAS , focuses on how cells regulate glycolysis to maintain energy production under conditions of energy stress.
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