How enzymes locally block cell wall repair, allowing cells to fuse in an irreversible manner
University of Geneva researchers have identified a mechanism in yeast cells that prevents cell wall repair during fusion, making the process irreversible. This discovery provides insights into cellular reproduction and potential future targets for treating fungal infections.
Why it matters
Understanding the fundamental biology of fungal cell fusion could lead to new medical treatments for pathogenic fungi that affect humans and crops.
edited by Sadie Harley , reviewed by Robert Egan
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Add to Preferred Sources Yeast cells undergoing sexual reproduction, observed by fluorescence microscopy; the green signal reveals a cell wall damage sensor at the site of fusion. Credit: J. Coronas-Serna, UNIGE The fusion of two cells is a decisive event in the sexual reproduction of many organisms. In fungi, cells must not only bring their membranes together and merge them, but also locally open their protective cell wall.
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