Hidden stem cells may be fueling spinal stenosis

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have identified a previously elusive population of stem cells that appears to produce the body's tendons and ligaments, the connective tissues that link muscles and bones.

The scientists also found evidence that these cells can become overactive in the lower spine, where they may contribute to lumbar spinal stenosis. The condition affects an estimated 103 million people worldwide and develops when thickened ligaments reduce space inside the spinal canal. This narrowing can put pressure on nerves and lead to pain, numbness and difficulty walking.

The study, published Sept. 7 in Cell , raises the possibility that targeting these stem cells could eventually lead to new treatments for spinal stenosis. One potential approach may involve drugs already used to control high blood pressure.