Hidden lymphatic signal amplifier could inform treatments for lymphedema and cancer metastasis
Researchers from KAIST and the Institute for Basic Science have identified how the VEGF-C–VEGFR-3 complex clusters to amplify signaling in lymphatic vessels. This discovery offers a potential new target for medical treatments related to lymphedema and cancer metastasis.
Why it matters
Understanding this signaling mechanism could lead to more effective therapies for managing swelling disorders and preventing the spread of cancer.
by The Korea Advanced Institute of Science and Technology (KAIST)
edited by Sadie Harley , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add as preferred source Cluster formation of the VEGFR-3/VEGF-C complex and signal amplification When VEGFR-3 was mutated to disrupt cis-cluster formation, the activation of VEGFR-3 and ERK was markedly reduced despite VEGF-C stimulation. This confirms that cis-clustering is critical for signal amplification. Credit: KAIST Lymphatic vessels act as the body's "drainage system," collecting excess fluid from tissues. When lymphatic drainage is impaired because lymphatic vessels are underdeveloped, damaged or dysfunctional, lymphedema can develop, causing swelling, particularly in the arms and legs.
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