Heterogeneity in the response to the metabolic environment drives fosfomycin heteroresistance
Researchers have discovered that glucose availability in the metabolic environment influences fosfomycin heteroresistance in Enterobacter cloacae by regulating the GlpT importer. This finding suggests that a patient's metabolic state, such as hyperglycemia, may impact the effectiveness of antibiotic treatments.
Why it matters
Understanding how metabolic environments drive antibiotic resistance could lead to more personalized and effective treatment strategies for infections in patients with specific underlying health conditions.
Nature Communications ( 2026 ) Cite this article
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