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Nature·5 min read·hard

Gene ancestries reveal diverse microbial associations during eukaryogenesis

Gene ancestries reveal diverse microbial associations during eukaryogenesis
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Researchers have used advanced phylogenomic analysis to reconstruct the proteome of the last eukaryotic common ancestor (LECA). The study suggests that early eukaryotes evolved through complex microbial interactions and horizontal gene transfers involving bacteria and viruses.

Why it matters

This research provides a significant update to our understanding of the origins of complex life, highlighting the role of symbiotic relationships and viral influence in evolutionary history.

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The origin of eukaryotes remains a central enigma in biology 1 . Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon 2 , 3 . However, the nature, timing and contributions of other potential bacterial partners 4 , 5 , 6

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