Enrique Grande: Rethinking Bladder Preservation in Muscle
Oncologist Enrique Grande discusses the limitations of using clinical complete response as a surrogate for pathologic clearance in muscle-invasive bladder cancer treatment. He emphasizes that bladder preservation requires rigorous prospective validation before replacing standard cystectomy.
Why it matters
The findings challenge current treatment protocols for bladder cancer, suggesting that existing diagnostic tools may miss residual disease in a significant portion of patients.
Enrique Grande , One Oncology Madrid Program Director at Quironsalud, shared on X :
“pCR rates of 55 – 57% with perioperative EV + pembrolizumab in MIBC are real.
But clinical complete response is not a reliable surrogate for pathologic clearance. 52% of patients with endoscopic cCR still harbor residual tumor at cystectomy.
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