EHD2 Protein Chain Stabilizes Caveolae

Our cells’ membranes have many functions. They not only provide mechanical protection, but also precisely control which substances enter or leave the cells. If they fail to perform these tasks, disease can result. Their structure is correspondingly complex: The outer cell membrane, for example, often features bottle-shaped invaginations called caveolae. Among others, they protect the cells of blood vessels, which are frequently exposed to strong mechanical forces. In addition, caveolae serve as signaling centers that help regulate blood pressure. Cells also absorb nutrients - especially fatty acids - via caveolae. Researchers at the Max Delbrück Center have now discovered how caveolae - which are found in nearly all cells of our body - are stabilized to the outer cell membrane. ​“A chain of protein molecules wraps around the neck of these bottle-shaped structures to support them,” explains Dr.