Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy
This study examined the impact of chronic sleep disruption in early adulthood on the progression of tauopathy in a mouse model of Alzheimer's disease. Results showed that sleep-deprived mice unexpectedly performed better in spatial learning tasks, though they exhibited signs of sustained microglial proliferation.
Why it matters
The findings challenge existing assumptions about the direct link between sleep loss and cognitive decline in tauopathy, suggesting complex neurobiological interactions.
Scientific Reports ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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