'DNA Typewriter' records cells' history in developing mouse embryo
Researchers have utilized a new technology called 'DNA Typewriter' to record the developmental history of cells in a mouse embryo. By inserting a recording device into the genome, scientists successfully mapped the family tree of cells over 13.5 days of gestation.
Why it matters
This breakthrough provides a powerful tool for understanding how early cell ancestry influences later development, which could lead to advancements in treating congenital disorders and cancer.
by University of Washington School of Medicine
edited by Gaby Clark , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add to Preferred Sources DNA Typewriter is injected into the genetic material of a fertilized mouse egg. This technology taps into the genetic material in the fertilized egg and resulting embryonic cells as a recording device of the cells' histories. It tracks their relationships as the embryo develops. Credit: Kyle O'Conner/Seattle Hub for Synthetic Biology Scientists have succeeded in reconstructing the family tree of cells in a developing mouse embryo. They recorded cells' relationships, starting when the fertilized egg first split in two and ending after the body and its organs took shape. That period lasted 13.5 days. (Full gestation in mice is 19 to 21 days.)
Get smarter about the news
Sign up free for a feed built around what you actually care about, Dive Deeper research on any story, and the full text of every article.
Create free accountAlready have an account? Sign in