Deficiency of non-muscle myosin IIA promotes neuroinflammation by impairing autophagic degradation of VCAM-1 in brain endothelium
Researchers have identified that the deficiency of the protein NMIIA in brain endothelial cells leads to neuroinflammation by disrupting the autophagic degradation of VCAM-1. This process contributes to cognitive decline and neuronal damage in aging models.
Why it matters
Understanding this molecular pathway provides potential therapeutic targets for treating age-related neurodegenerative diseases and neurovascular disorders.
Scientific Reports ( 2026 ) Cite this article
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