Decoding the mechanisms of cooperative DNA binding by the Paired-like homeodomain family
Researchers have identified 11 rules governing how Paired-like homeodomain transcription factors cooperatively bind to DNA. The study links specific missense variants in these proteins to the disruption of cooperative binding and various human diseases.
Why it matters
Understanding these molecular mechanisms provides critical insights into how genetic mutations contribute to developmental disorders and disease.
Nature Communications ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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