D-serine accelerates gastric tumor growth by suppressing killer T cells

edited by Sadie Harley , reviewed by Robert Egan

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Add as preferred source D-serine is a metabolic byproduct that aids immune evasion by gastric cancer tumors. It increases immunosuppressive macrophage activity and reduces the numbers and function of cytotoxic T cells. This aids tumor growth and provides resistance against immune checkpoint inhibitor therapy. Credit: Keio University Global Research Institute (KGRI) One of the crucial steps in cancer proliferation is evading killer immune cells. Cancer cells use a variety of signaling molecules to evade the immune system. Immune checkpoint inhibitor (ICI) therapy interferes with some of these evasion tactics, improving the immune system's ability to suppress tumors. However, the success of ICI therapy depends on the specific signals being secreted by the tumor.