Cyclosporin A triggers a RIG-I-mediated interferon response through multiple cellular processes

This scientific report details how Cyclosporin A (CsA), an immunosuppressant, triggers an antiviral response by activating the RIG-I/IFN-λ/ISG signaling axis. The study reveals that CsA's antiviral activity is linked to mitochondrial remodeling, dsRNA accumulation, and impaired autophagy, offering new mechanistic insights.