Creating new 3D models to test drugs in pediatric sarcoma: A postdoc's recipe for research
Postdoctoral researcher Allison Reno is applying techniques from baking, such as temperature-controlled polymerization, to create 3D hydrogel models for testing pediatric sarcoma drugs. These models provide a more accurate human-like environment for drug screening than traditional animal testing.
Why it matters
Innovative bioengineering methods can accelerate cancer research and improve the efficacy of drug testing for pediatric patients.
by Leslie Cantu, Medical University of South Carolina
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add as preferred source Allison Reno, Ph.D., is a fellow at MUSC Hollings Cancer Center. Credit: Medical University of South Carolina The Great British Bake Off offers drama, baking tips and—for one viewer in South Carolina—inspiration for creating 3D models that can be used to test cancer drugs.
"I borrow techniques sometimes," said Allison Reno, Ph.D. "I see them do things that work very well for chocolate or gelatin in baking, like temperature changes. Similar principles apply to hydrogel polymerization. We can induce polymerization through rapid temperature changes, acid-based reactions and/or gentle mixing. We use a combination of those three to create a really, really strong gel."
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