Complement C3a receptor expression is associated with distinct immune microenvironmental profiles in clear cell renal cell carcinoma
Researchers have identified that the expression of the C3a receptor (C3aR) in clear cell renal cell carcinoma is linked to specific immune microenvironments, particularly within myeloid cells. The study suggests that C3aR expression correlates with CD4+ T-cell infiltration and may serve as a potential biomarker for tumor-immune interactions.
Why it matters
Understanding the role of C3aR in kidney cancer could lead to more targeted immunotherapies and better prognostic tools for patients.
Scientific Reports ( 2026 ) Cite this article
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