Columbia scientists discover surprising link between serotonin and heart valve disease

Researchers at Columbia University have identified a link between serotonin transporter activity and the progression of degenerative mitral regurgitation in the heart. The study suggests that reduced serotonin activity may accelerate damage to the mitral valve.
Why it matters
Understanding the biological mechanisms behind heart valve disease could lead to new therapeutic targets for patients suffering from mitral regurgitation.
Serotonin is usually associated with mood, sleep, and digestion. But research published in 2023 suggests this chemical messenger may also influence a small structure that performs a vital job during every heartbeat: the mitral valve.
The article provides a summary of scientific research findings without bias.
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