Cleveland Research Team Identifies Biological Mechanism That May Explain Obesity Relapse
Researchers at Case Western Reserve University have identified a biological mechanism involving the hormone asprosin that may explain why weight regain occurs after dieting. This 'obesity memory' in fat cells can also be transmitted from mother to child, potentially explaining intergenerational obesity trends.
Why it matters
Understanding the biological roots of obesity relapse could lead to more effective medical treatments and interventions for the global obesity epidemic.
Graphical Abstract (Figure 7) is designed to tell the whole story at a glance. It visually contrasts the lean state, obesity, and after weight loss on the left, and the maternal transmission on the right.
Newswise — CLEVELAND -- Two enduring biological mysteries have remained unsolved for decades: why almost everyone who loses weight gains it back, no matter how they lost it, and why obesity passes from mother to child at rates that diet and environment cannot explain. Now, scientists from Harrington Discovery Institute at University Hospitals and Case Western Reserve University have identified why.
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