Cleveland Clinic Finds Gut Bacteria Tied to Heart Rhythm
A Cleveland Clinic study has identified a link between high levels of TMAO, a byproduct of gut bacteria digesting red meat, and an increased risk of atrial fibrillation. The findings suggest that dietary interventions could potentially lower the risk of heart rhythm disorders.
Why it matters
This research provides a potential non-surgical pathway for managing heart health through microbiome and dietary management.
-led study shows a connection between elevated blood levels of TMAO (trimethylamine N-oxide) - a byproduct of gut bacteria digestion of nutrients found in red meat and other animal products - and a higher risk of atrial fibrillation.
The research team, led by Robert Koeth, M.D., Ph.D ., analyzed blood samples from more than 5,000 people undergoing heart procedures. The researchers also conducted laboratory studies in cells to better understand how TMAO may influence the heart. They discovered that gut microbe-produced TMAO changes the heart's electrical environment, increasing susceptibility to abnormal rhythms. Findings were published today in the Journal of Clinical Investigation.
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