Circular mRNA helps cell factories make up to six times as much protein

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Add as preferred source Conceptual image illustrating CRESEnT technology, which circularizes linear mRNA inside microbial cells to increase protein production. Credit: Seoul National University College of Engineering A synthetic biology technology has been developed that converts easily degraded messenger RNA (mRNA) into a ring-shaped form inside microbial cells, increasing protein production.

A research team led by Professor Sang Woo Seo of the Department of Chemical and Biological Engineering at Seoul National University College of Engineering has developed a synthetic biology technology that converts linear mRNA into a circular form inside microbial cells, simultaneously increasing mRNA stability and protein production efficiency. The team named the technology CRESEnT (Circular RNA Expression for Stable and Enhanced Translation).