Cigarette smoke linked to different lung cancer types - News-Medical
Researchers at Johns Hopkins University have linked cigarette smoke exposure to specific lung cancer mutations in laboratory organoids. The study demonstrates how smoke alters stem cells and suppresses immune pathways, creating a environment for tumor growth.
Why it matters
This research provides a clearer biological understanding of how smoking causes cancer, potentially leading to better diagnostic and preventative strategies.
--> Long-term exposure to cigarette smoke can alter lung stem cells, making them more vulnerable to certain cancer-related mutations. Researchers at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University established this in experiments using organoids—three-dimensional laboratory models of tissues. News-Medical reports on the findings, published on October 5 in the journal Proceedings of the National Academy of Sciences.
The scientists created organoids from normal mouse lung tissue and exposed them to cigarette smoke condensate—a mixture of chemicals and particles contained in smoke—for six months. Key early findings were also tested in organoids from normal human lung tissue.
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