NBC Sports·3 min read·easy

Cardinals beat Chargers in NFL's biggest upset of Week 1

M
Michael David Smith
Cardinals beat Chargers in NFL's biggest upset of Week 1
AI Summary

The Arizona Cardinals secured a major upset victory over the Los Angeles Chargers in the NFL's Week 1, winning 26-14. The game featured a strong performance by Cardinals quarterback Jacoby Brissett and a disappointing showing from the Chargers under new coach Jim Harbaugh.

Why it matters

The result challenges preseason expectations and highlights the volatility of early-season NFL performance.

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The Chargers were 9.5-point favorites against the Cardinals today in Los Angeles, the biggest betting line in the NFL for Week 1. No one thought this was a game Arizona would win.

In a major upset that may force us to reassess what we thought we knew about both teams, the Cardinals went to Los Angeles and beat the Chargers 26-14.

First-year Cardinals head coach Mike LaFleur deserves an enormous amount of credit for having his team ready to play, and Chargers head coach Jim Harbaugh will face plenty of questions about why his team wasn’t. Harbaugh had previously been 6-0 in Week 1 in his NFL coaching career.

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