Blood vessel building revealed: Cells push, anchor and pull to connect flowing channels
Researchers at the University of Basel have identified the cellular mechanisms, specifically pushing and pulling forces, that allow blood vessels to connect and form continuous channels. This discovery aids in the future development of vascularized organoids.
Why it matters
Understanding vascular development is essential for medical advancements in tissue engineering and regenerative medicine.
edited by Sadie Harley , reviewed by Andrew Zinin
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Add as preferred source Blood vessels (green) of a zebrafish, filled with blood cells (red). Credit: Etienne Schmelzer, Biozentrum, University of Basel How do blood vessels form to reliably supply the body with oxygen and nutrients? A research team at the University of Basel has uncovered a key mechanism by which cells join to build new blood vessels.
Their study reveals how pushing and pulling forces enable individual vessel segments to connect and form a continuous blood vessel. The findings deepen our understanding of vascular development and provide a foundation for developing vascularized organoids.
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