Blood-Brain Chip Predicts Glioblastoma Treatment Response
Researchers at KAIST and partner institutions have developed a microfluidic chip that mimics the blood-brain barrier to predict how individual glioblastoma patients will respond to specific drugs. This technology addresses the challenge of patient-specific tumor environments, which often cause standard treatments to fail.
Why it matters
This innovation could significantly improve survival rates for glioblastoma patients by enabling personalized treatment plans that bypass the limitations of the blood-brain barrier.
Even for the same brain tumor treated with the same anticancer drug, the effect can differ from patient to patient. A Korean research team has developed a chip that recreates a patient's own tumor cells together with the surrounding peritumoral vascular environment, making it possible to predict patient-specific treatment responses in advance.
KAIST (President Choongsik Bae) announced on August 18 that a research team led by Professor Song Ih Ahn from the Department of Mechanical Engineering, in collaboration with Professor Jungho Ahn's team at Sungkyunkwan University, Professor Jaejoon Lim of CHA Bundang Medical Center, and Professor Youn-Jung Kang's team at CHA University, has developed a patient-specific blood - brain tumor barrier (BBTB) chip capable of predicting treatment responses in glioblastoma patients.
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