Blocking gene boosts T-cell attacks on chronic hepatitis B virus and tumors

by Zhang Nannan, Chinese Academy of Sciences

edited by Gaby Clark , reviewed by Robert Egan

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Add as preferred source Proposed dynamics of antigen-specific CD8 + T cell populations regulated by Ankrd11 in chronic infection and cancer. Credit: Zhou Xuyu's group A research team led by Professor Zhou Xuyu from the Institute of Microbiology of the Chinese Academy of Sciences (CAS), in collaboration with researchers from Beijing Ditan Hospital and Capital Medical University, has identified ANKRD11 as a key regulator that reduces the activity of CD8 + T cells during chronic hepatitis B virus (HBV) infection and cancer. The researchers found that ANKRD11 suppresses the AP-1 signaling pathway, which usually helps CD8 + T cells mount effective responses against infections and tumors.