Behavioral characterization of 5xFAD mice using standardized decision-making and open field assays
A study published in Scientific Reports found that 5xFAD mice, a model for Alzheimer's disease, did not exhibit behavioral deficits despite significant amyloid plaque accumulation. The findings suggest that current behavioral assays may not be sensitive enough to detect early-stage functional impairment.
Why it matters
This research challenges existing assumptions in Alzheimer's disease modeling, emphasizing the need for more precise diagnostic and functional testing methods.
Scientific Reports ( 2026 ) Cite this article
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.
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