Baseline clinical features outperform structural MRI in predicting rapid cognitive and motor decline in Parkinson’s disease
A study published in Nature indicates that baseline clinical features are more effective than structural MRI scans at predicting rapid cognitive and motor decline in Parkinson's disease patients. The research suggests that clinical assessments provide better prognostic utility for individual-level disease progression.
Why it matters
Improving early-stage prognostic markers is critical for identifying patients who would benefit most from disease-modifying therapies and for enhancing the design of clinical trials.
npj Parkinson's Disease ( 2026 ) Cite this article
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.
Get smarter about the news
Sign up free for a feed built around what you actually care about, Dive Deeper research on any story, and the full text of every article.
Create free accountAlready have an account? Sign in