Autoantibodies could play key role in cancer progression and prevention

Scientists are investigating the role of autoantibodies in cancer progression and prevention as part of a new research initiative. The study aims to determine if these immune proteins can be used for better risk assessment and treatment strategies.
Why it matters
Identifying the dual role of autoantibodies could revolutionize how doctors screen for and treat various types of cancer.
Jean-Laurent Casanova, M.D., Ph.D., is Professor in the Center for the Genetics of Host Defense and Children’s Medical Center Research Institute at UT Southwestern. He also has dual appointments in Pediatrics and Immunology.
Newswise — DALLAS - July 23, 2026 - Scientists have long sought to understand why some people with no known risk factors develop cancer while others with significant risk never do. The answer may lie in immune proteins known as autoantibodies (auto-Abs), suggests a commentary in Cell co-authored by a team that includes Jean-Laurent Casanova, M.D., Ph.D., Professor in the Center for the Genetics of Host Defense and Children's Medical Center Research Institute at UT Southwestern (CRI) .
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