ATF6 shapes PERK and IRE1 signaling dynamics during ER stress
A study published in Cell Death & Disease reveals that the protein ATF6 acts as a temporal modulator of the Unfolded Protein Response (UPR) by interacting with PERK and IRE1 signaling pathways. This discovery clarifies how cells manage ER stress over time.
Why it matters
Advances the fundamental understanding of cellular stress responses, which is critical for research into diseases linked to protein misfolding.
Cell Death & Disease ( 2026 ) Cite this article
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.
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