Aspirin Rarely Used for Colorectal Cancer Prevention: Fewer than one in ten people with Lynch syndrome take Acetylsalicylic acid to prevent cancer – despite a high level of openness to new preventive

A study reveals that aspirin is underutilized as a preventative measure for colorectal cancer among patients with Lynch syndrome. Researchers suggest that a low daily dose of 100mg could be an effective and well-tolerated option for high-risk individuals.
Why it matters
Improving the adoption of preventative medication could significantly reduce cancer incidence in genetically predisposed populations.
Newswise — According to international studies, taking Acetylsalicylic acid daily can protect people with Lynch syndrome from developing colorectal cancer - even at low doses. Researchers from the University Hospital Bonn (UKB), the University of Bonn, and the Center for Integrated Oncology (CIO) Bonn, in collaboration with the self-help organization SemiColon, have now found that these scientific findings have so far been insufficiently incorporated into clinical practice. The results of the LYNX study have now been published as a letter in the journal *The Lancet Gastroenterology & Hepatology *. People with Lynch syndrome have a significantly increased risk of developing colorectal cancer and other types of cancer due to a hereditary predisposition. The CAPP2 study had already shown in this high-risk group that Acetylsalicylic acid can significantly reduce the long-term risk of colorectal cancer. The study examined a comparatively high daily dose of 600 milligrams.
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