Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain
Researchers have identified how allele-specific chromatin architecture regulates imprinted genes in the mouse cortex. The study reveals that distal enhancers and antisense transcription coordinate to control gene expression based on parental origin.
Why it matters
Understanding these genomic mechanisms provides deeper insight into developmental biology and the regulation of imprinted disorders.
Nature Communications ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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