Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain
Researchers have identified how allele-specific chromatin architecture regulates imprinted genes in mouse neurons. The study reveals that a distal enhancer coordinates maternal and paternal gene expression, providing new insights into genomic imprinting mechanisms.
Why it matters
Understanding these genetic mechanisms is crucial for advancing knowledge in developmental biology and potential future therapies for imprinting-related disorders.
Nature Communications ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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