AI-designed proteins enable a new generation of RNA transporters
Researchers at Helmholtz Munich and the Technical University of Munich have developed a new RNA delivery system using AI-designed protein scaffolds. These synthetic structures, which differ significantly from natural viral capsids, offer a more efficient and selective way to transport therapeutic RNA into cells.
Why it matters
This breakthrough could significantly improve the efficacy and safety of RNA-based gene therapies and vaccines by overcoming the limitations of current lipid nanoparticle and viral delivery methods.
by Helmholtz Association of German Research Centres
edited by Gaby Clark , reviewed by Robert Egan
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Add as preferred source Design and screening of bottom-up-assembled STV RNA carrier. Credit: Nature (2026). DOI: 10.1038/s41586-026-10952-3 RNA-based therapeutics use RNA as a blueprint that enables cells to produce specific proteins—including proteins that can precisely modify genes. For this to work, the RNA must reach the inside of the cell intact. Delivery systems currently used for this purpose include virus-derived vehicles and lipid nanoparticles, tiny particles made of fat-like molecules. Both approaches have limitations. Researchers are therefore working on new mechanisms that can deliver RNA into cells more efficiently and, in the future, more selectively.
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