Adrian Lee: 3 New Papers Set to Transform Organoid
Three new research papers published in Nature Portfolio validate the use of patient-derived 3D organoids as advanced tools for cancer research. These studies expand the Cancer Dependency Map, offering better models for studying tumor subtypes than traditional 2D cell cultures.
Why it matters
This research represents a significant technical advancement in precision oncology, potentially accelerating the development of targeted cancer therapies.
Adrian Lee , Professor at University of Pittsburgh, shared on LinkedIn :
“Organoid biology and precision oncology – three companion papers just published together in Nature Portfolio , all validating patient-derived 3D cancer models as the next generation of preclinical tools.
Deep thanks to the Broad Institute team, including James N ., Francisca Vazquez , and many others for leading ‘A dependency map enhanced with next-generation 3D cancer models,’ which Steffi Oesterreich , Daniel D. Brown, and I were proud to contribute to.
This is exactly the mission of the University of Pittsburgh School of Medicine Organoid Research Core within our Institute for Precision Medicine , so it’s gratifying to see it validated at this scale
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