A massively parallel CRISPR-based screening platform for modifiers of neuronal depolarization
Researchers have developed a new CRISPR-based screening platform to study how specific genes influence neuronal depolarization. By testing over 1,300 genes in human iPSC-derived neurons, the study identifies potential genetic links to neurodegenerative and neurodevelopmental conditions like Alzheimer's and autism.
Why it matters
This platform provides a scalable tool for identifying molecular targets in neurological disorders, potentially accelerating the development of new therapeutic interventions.
Nature Communications ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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