49ers vs. Rams prediction, odds, time: 2026 NFL Australian Game expert picks
The San Francisco 49ers and Los Angeles Rams are set to face off in a season-opening NFL game in Melbourne, Australia. Betting experts are analyzing the odds as both teams look to build on their successful 2025 campaigns.
Why it matters
The game represents the NFL's continued efforts to expand its international footprint and engage global audiences.
NFC West rivals and Super Bowl contenders clash when the San Francisco 49ers battle the Los Angeles Rams in a season-opening matchup in Melbourne, Australia on Thursday. L.A. and San Fran tied for second in the division at 12-5 in 2025. The Rams are looking to reach their third Super Bowl in nine seasons, and first since winning Super Bowl LVI during the 2021 season. The 49ers, meanwhile, are looking to reach their third Super Bowl in eight seasons. Aaron Donald did not make the trip to Australia as his Rams return will have to wait. New to sports trading? Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS :
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