3D DNA mapping in rare immune cells reveals new genes linked with autoimmune disease risk
Researchers have used 3D DNA mapping to identify how enhancers loop to regulate genes in rare immune cells. This discovery helps explain the genetic basis of autoimmune conditions like Crohn's disease, potentially paving the way for new targeted treatments.
Why it matters
Understanding the 3D architecture of DNA provides critical insights into the genetic roots of complex diseases that currently lack cures.
by Emily Armstrong, MRC Laboratory of Medical Sciences
edited by Swati Mestri , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add as preferred source Credit: CC0 Public Domain Our DNA is often pictured as a simple spiral, like a piece of rope held taut. But inside cells, it folds into a complex three-dimensional structure, with 2 meters (6.6 feet) of DNA scrunched like a headphone wire in a pocket. This bundled architecture plays a crucial role in how genes are switched on and off. Understanding these interactions is key to interpreting genetic studies of disease and can help develop targeted treatments.
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